Aldo-Keto Reductases

Preferred Label : Aldo-Keto Reductases;

MeSH definition : A family of NADPH-dependent oxidoreductases that reduce carbonyl substrates including sugar-aldehydes, KETOSTEROIDS; keto-prostaglandins, and QUINONES. They are monomers of approximately 37 KDa and are characterized by a parallel beta-8 (BETA SHEET)-alpha 8 (ALPHA HELICES)-barrel structure that contains the NADP binding site. This conformation favors aromatic and apolar substrates.;

MeSH synonym : Aldo Keto Reductases; Reductases, Aldo-Keto; Aldo-Keto Reductase Superfamily; Aldo Keto Reductase Superfamily; Aldo-Keto Reductase Family; Aldo Keto Reductase Family;

DeCS synonym : Aldo-Keto Reductase;

MeSH hyponym : Aldo Keto Reductase; Reductase, Aldo-Keto;

Registry Number MeSH : EC 1.1.1.-;

Details

Origin ID

D000074408;

UMLS CUI

C4317070;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Aldo-keto reductase family 1, member c4 [OMIM gene]
Record concept(s)
- Aldo-Keto Reductase [MeSH concept]
- Aldo-Keto Reductases [MeSH concept]
Related MeSH Supplementary Concept(s)
- AKR1B10 protein, human [MeSH Supplementary Concept]
- AKR1C19 protein, mouse [MeSH Supplementary Concept]
- AKR7A5 protein, mouse [MeSH Supplementary Concept]
- Akr1b10 protein, mouse [MeSH Supplementary Concept]
- Akr1b3 protein, mouse [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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