MeSH definition : An AAA ATPase that binds and severs MICROTUBULES. It specifically recognizes and cuts
polyglutamylated microtubules with short polyglutamate tails to promote reorganization
of cellular microtubule arrays and the release of microtubules from the CENTROSOME
following nucleation. It is critical for the biogenesis and maintenance of complex
microtubule arrays in AXONS; SPINDLE APPARATUS; and CILIA. Mutations in the spastin
gene (SPAST) are associated with type 4 of HEREDITARY SPASTIC PARAPLEGIA.;
An AAA ATPase that binds and severs MICROTUBULES. It specifically recognizes and cuts
polyglutamylated microtubules with short polyglutamate tails to promote reorganization
of cellular microtubule arrays and the release of microtubules from the CENTROSOME
following nucleation. It is critical for the biogenesis and maintenance of complex
microtubule arrays in AXONS; SPINDLE APPARATUS; and CILIA. Mutations in the spastin
gene (SPAST) are associated with type 4 of HEREDITARY SPASTIC PARAPLEGIA.