Serine Peptidase Inhibitor Kazal-Type 5

Preferred Label : Serine Peptidase Inhibitor Kazal-Type 5;

MeSH definition : A secreted serine peptidase inhibitor that consists of 15 KAZAL MOTIFS and inhibits KALLIKREINS KLK5, KLK7, and KLK14 as well as TRYPSIN. It plays important roles in protecting MUCOSA against infection and inflammation, and in maintaining the integrity of the skin. Mutations in the SPINK5 gene are associated with NETHERTON SYNDROME.;

MeSH synonym : Serine Peptidase Inhibitor Kazal Type 5; LEKTI Protein; SPINK5 Protein; Serine Protease Inhibitor Kazal-Type 5; Serine Protease Inhibitor Kazal Type 5; Lympho-Epithelial Kazal-Type Inhibitor; Inhibitor, Lympho-Epithelial Kazal-Type; Kazal-Type Inhibitor, Lympho-Epithelial; Lympho Epithelial Kazal Type Inhibitor;

Details

Origin ID

D000074163;

UMLS CUI

C4505200;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Serine protease inhibitor, kazal-type, 5 [OMIM gene]
- serine peptidase inhibitor Kazal type 5 [ORDO Gene]
- serine peptidase inhibitor Kazal type 5 [HGNC gene]
Record concept(s)
- Serine Peptidase Inhibitor Kazal-Type 5 [MeSH concept]
Related MeSH Supplementary Concept(s)
- SPINK5 protein, human [MeSH Supplementary Concept]
- Spink5 protein, mouse [MeSH Supplementary Concept]
See also
- Kazal Motifs [MeSH Descriptor]
- netherton syndrome [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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