Preferred Label : Protein Kinase C-theta;
MeSH definition : A calcium-independent, phospholipid- and diacylglycerol-dependent, protein kinase
C subtype that contains an N-terminal C2 DOMAIN and two diacylglycerol-binding ZINC
FINGERS. It is expressed primarily by T-LYMPHOCYTES and localizes to IMMUNOLOGICAL
SYNAPSES where it regulates downstream signaling for the activation, proliferation,
and survival of mature T-cells. It plays a critical role in allergic, autoimmune,
and alloimmune responses of TH2 CELLS and TH17 CELLS.;
MeSH synonym : Protein Kinase C, theta; PRKCQ; Protein Kinase C theta; PKC-theta; PKC theta;
Registry Number MeSH : EC 2.7.11.13;
UNII : EC 2.7.11.13;
Origin ID : D000074121;
UMLS CUI : C4319709;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- Semantic type(s)
A calcium-independent, phospholipid- and diacylglycerol-dependent, protein kinase
C subtype that contains an N-terminal C2 DOMAIN and two diacylglycerol-binding ZINC
FINGERS. It is expressed primarily by T-LYMPHOCYTES and localizes to IMMUNOLOGICAL
SYNAPSES where it regulates downstream signaling for the activation, proliferation,
and survival of mature T-cells. It plays a critical role in allergic, autoimmune,
and alloimmune responses of TH2 CELLS and TH17 CELLS.
