Preferred Label : Copper-transporting ATPases;
MeSH definition : P-type ATPases which transport copper ions across membranes in prokaryotic and eukaryotic
cells. They possess a conserved CYSTEINE-HISTIDINE-SERINE (CPx) amino acid motif within
their transmembrane helices that functions in cation translocation and catalytic activation,
and an N-terminal copper-binding CxxC motif that regulates enzyme activity. They play
essential roles in intracellular copper homeostasis through regulating the uptake,
efflux and storage of copper ions, and in cuproprotein biosynthesis.;
MeSH synonym : ATPases, Copper-transporting; Copper transporting ATPases; Cu( )-transporting ATPases; Copper-transporting Adenosine Triphosphatases; Adenosine Triphosphatases, Copper-transporting; Copper transporting Adenosine Triphosphatases; Triphosphatases, Copper-transporting Adenosine; Copper-transporting ATPase; ATPase, Copper-transporting; Copper transporting ATPase; Cu-transporting ATPases; ATPases, Cu-transporting; Cu transporting ATPases;
DeCS synonym : Wilson Disease Protein; Copper-transporting ATPase 1; Pineal Night-specific ATPase;
MeSH hyponym : ATP7B Cu-binding P type ATPase; ATP7B Cu binding P type ATPase; Copper-transporting ATPase 2; Copper transporting ATPase 2; ATPase, Cu transporting, beta Polypeptide (Wilson Disease); Wilson Disease Cu-binding P Type ATPase; Wilson Disease Cu binding P Type ATPase; ATPase 1, Copper-transporting; Copper transporting ATPase 1; Copper Pump 1; Menkes Disease-associated Protein; Menkes Disease associated Protein; ATP7A Protein; ATPase Copper Transporting alpha; ATPase, Pineal Night-specific; Night-specific ATPase, Pineal; Pineal Night specific ATPase; PINA Enzyme; ATPase 2, Copper-Transporting;
MeSH Related Number : EC 3.6.3.54;
Registry Number MeSH : EC 3.6.3.54;
UNII : EC 7.2.2.8;
Origin ID : D000073840;
UMLS CUI : C4505125;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- See also
- Semantic type(s)
P-type ATPases which transport copper ions across membranes in prokaryotic and eukaryotic
cells. They possess a conserved CYSTEINE-HISTIDINE-SERINE (CPx) amino acid motif within
their transmembrane helices that functions in cation translocation and catalytic activation,
and an N-terminal copper-binding CxxC motif that regulates enzyme activity. They play
essential roles in intracellular copper homeostasis through regulating the uptake,
efflux and storage of copper ions, and in cuproprotein biosynthesis.
