Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases

Preferred Label : Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases;

MeSH definition : Phosphoinositide phosphatases that catalyze the dephosphorylation (hydrolysis) of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) to produce PtdIns(3,4)P(2), which negatively regulates the PI3K ( 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES) pathways. They contain an SH2 DOMAIN and STERILE ALPHA MOTIF and have important functions in regulating the immune response and other cellular processes in vertebrates.;

MeSH synonym : Src Homology 2 Domain-Containing Inositol Phosphatases; Src Homology 2 Domain Containing Inositol Phosphatases; SHIP Phosphatases; Phosphatases, SHIP;

Registry Number MeSH : EC 3.1.3.86;

UNII : EC 3.1.3.86;

Details

Origin ID

D000072183;

UMLS CUI

C4277587;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Record concept(s)
- Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases [MeSH concept]
Related MeSH Supplementary Concept(s)
- INPP5D protein, human [MeSH Supplementary Concept]
- INPPL1 protein, human [MeSH Supplementary Concept]
- Inpp5d protein, mouse [MeSH Supplementary Concept]
- Inppl1 protein, mouse [MeSH Supplementary Concept]
- Inppl1 protein, rat [MeSH Supplementary Concept]
- inpp5d protein, zebrafish [MeSH Supplementary Concept]
- inppl1a protein, zebrafish [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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