" /> Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases - CISMeF





Preferred Label : Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases;

MeSH definition : Phosphoinositide phosphatases that catalyze the dephosphorylation (hydrolysis) of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) to produce PtdIns(3,4)P(2), which negatively regulates the PI3K ( 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES) pathways. They contain an SH2 DOMAIN and STERILE ALPHA MOTIF and have important functions in regulating the immune response and other cellular processes in vertebrates.;

MeSH synonym : Src Homology 2 Domain-Containing Inositol Phosphatases; Src Homology 2 Domain Containing Inositol Phosphatases; SHIP Phosphatases; Phosphatases, SHIP;

Registry Number MeSH : EC 3.1.3.86;

UNII : EC 3.1.3.86;

Détails


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Phosphoinositide phosphatases that catalyze the dephosphorylation (hydrolysis) of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) to produce PtdIns(3,4)P(2), which negatively regulates the PI3K ( 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES) pathways. They contain an SH2 DOMAIN and STERILE ALPHA MOTIF and have important functions in regulating the immune response and other cellular processes in vertebrates.

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31/07/2025


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