Kelch-Like ECH-Associated Protein 1

Preferred Label : Kelch-Like ECH-Associated Protein 1;

MeSH definition : An adaptor protein characterized by an N-terminal BTB-POZ DOMAIN and six KELCH REPEATS that functions as a substrate for the E3 UBIQUITIN LIGASE complex. It negatively-regulates NF-E2-RELATED FACTOR 2 by targeting it for ubiquitination and degradation by the PROTEASOME. It also represses genes regulated by ANTIOXIDANT RESPONSE ELEMENTS.;

MeSH synonym : Kelch Like ECH Associated Protein 1; KEAP-1 Protein; KEAP 1 Protein; KEAP1 Protein;

Details

Origin ID

D000072019;

UMLS CUI

C3810577;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- KEAP1 Gene [NCIt concept]
- Kelch-Like ECH-Associated Protein 1 [NCIt concept]
- Kelch-like ech-associated protein 1 [OMIM gene]
- kelch like ECH associated protein 1 [ORDO Gene]
- kelch like ECH associated protein 1 [HGNC gene]
Record concept(s)
- Kelch-Like ECH-Associated Protein 1 [MeSH concept]
Related MeSH Supplementary Concept(s)
- KEAP1 protein, human [MeSH Supplementary Concept]
- KEAP1 protein, rat [MeSH Supplementary Concept]
- Keap1 protein, drosophila [MeSH Supplementary Concept]
- Keap1 protein, mouse [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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