Protein Phosphatase 2C

Preferred Label : Protein Phosphatase 2C;

MeSH definition : One of four major classes of mammalian serine/threonine specific protein phosphatases. Protein phosphatase 2C is a monomeric enzyme about 42 kDa in size. It shows broad substrate specificity dependent on divalent cations (mainly manganese and magnesium). Three isozymes are known in mammals: PP2C -alpha, -beta and -gamma. In yeast, there are four PP2C homologues: phosphatase PTC1 that have weak tyrosine phosphatase activity, phosphatase PTC2, phosphatase PTC3, and PTC4. Isozymes of PP2C also occur in Arabidopsis thaliana where the kinase-associated protein phosphatase (KAPP) containing a C-terminal PP2C domain, dephosphorylates Ser/Thr receptor-like kinase RLK5.;

MeSH synonym : 2C, Protein Phosphatase; Phosphatase 2C, Protein; PPM1 Protein Phosphatases; Phosphatases, PPM1 Protein; Protein Phosphatases, PPM1; Ptc2 Phosphatase; Phosphatase, Ptc2; PPM1 Magnesium-Dependent Protein Phosphatases; PPM1 Magnesium Dependent Protein Phosphatases;

DeCS synonym : Protein Phosphatase 2C delta; Protein Phosphatase 2C gamma; Magnesium-Dependent Protein Phosphatase 2C beta; Protein Phosphatase 2C epsilon; Protein Phosphatase 2C beta;

MeSH hyponym : PP2Cepsilon; PPM1E Phosphatase; Phosphatase, PPM1E; PP2C beta; beta, PP2C; Ppm1b Phosphatase; Phosphatase, Ppm1b; Protein Phosphatase 1D Magnesium-Dependent, delta isoform; Protein Phosphatase 1D Magnesium Dependent, delta isoform; PPM1D Phosphatase; Phosphatase, PPM1D; PP2Cgamma; PPM1G Phosphatase; Phosphatase, PPM1G; Magnesium Dependent Protein Phosphatase 2C beta;

MeSH Related Number : EC 3.1.3.-; EC 3.1.3.16; EC 3.1.3.43;

Registry Number MeSH : EC 3.1.3.16;

UNII : EC 3.1.3.16;

Details

Origin ID

D000071636;

UMLS CUI

C0247248;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Protein phosphatase, magnesium/manganese-dependent, 1g [OMIM gene]
- Protein phosphatase, magnesium/manganese-dependent, 1l [OMIM gene]
- protein phosphatase, Mg2+/Mn2+ dependent 1A [HGNC gene]
- protein phosphatase, Mg2+/Mn2+ dependent 1B [HGNC gene]
- protein phosphatase, Mg2+/Mn2+ dependent 1D [HGNC gene]
- protein phosphatase, Mg2+/Mn2+ dependent 1G [HGNC gene]
- protein phosphatase, Mg2+/Mn2+ dependent 1L [HGNC gene]
- pyruvate dehydrogenase phosphatase catalytic subunit 2 [HGNC gene]
Record concept(s)
- magnesium-dependent protein phosphatase 2C beta [MeSH concept]
- protein phosphatase 2C [MeSH concept]
- protein phosphatase 2C beta [MeSH concept]
- protein phosphatase 2C delta [MeSH concept]
- protein phosphatase 2C epsilon [MeSH concept]
- protein phosphatase 2C gamma [MeSH concept]
Related MeSH Supplementary Concept(s)
- AT2G33700 protein, Arabidopsis [MeSH Supplementary Concept]
- AT3G62260 protein, Arabidopsis [MeSH Supplementary Concept]
- AT4G38520 protein, Arabidopsis [MeSH Supplementary Concept]
- AT4g33920 protein, Arabidopsis [MeSH Supplementary Concept]
- EGR1 protein, Arabidopsis [MeSH Supplementary Concept]
- EGR2 protein, Arabidopsis [MeSH Supplementary Concept]
- EGR3 protein, Arabidopsis [MeSH Supplementary Concept]
- P2C-HA protein, Arabidopsis [MeSH Supplementary Concept]
- PDP1 protein, human [MeSH Supplementary Concept]
- PPM1A protein, human [MeSH Supplementary Concept]
- PPM1B protein, human [MeSH Supplementary Concept]
- PPM1D protein, human [MeSH Supplementary Concept]
- PPM1E protein, human [MeSH Supplementary Concept]
- PPM1G protein, human [MeSH Supplementary Concept]
- PPM1K protein, human [MeSH Supplementary Concept]
- PPTC7 protein, human [MeSH Supplementary Concept]
- PTC3 protein, S cerevisiae [MeSH Supplementary Concept]
- PTC4 protein, S cerevisiae [MeSH Supplementary Concept]
- PTC5 protein, S cerevisiae [MeSH Supplementary Concept]
- Pdp1 protein, mouse [MeSH Supplementary Concept]
- Ppm1a protein, mouse [MeSH Supplementary Concept]
- Ppm1b protein, mouse [MeSH Supplementary Concept]
- Ppm1d protein, mouse [MeSH Supplementary Concept]
- Ppm1d protein, rat [MeSH Supplementary Concept]
- Ppm1e protein, rat [MeSH Supplementary Concept]
- Ppm1k protein, mouse [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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