" /> Protein Deglycase DJ-1 - CISMeF





Preferred Label : Protein Deglycase DJ-1;

MeSH definition : A protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, releasing repaired proteins and lactate or glycolate. It deglycates CYSTEINE, ARGININE and LYSINE residues to reactivate proteins by reversing glycation and prevent the formation of ADVANCED GLYCATION END PRODUCTS. It protects cells against OXIDATIVE STRESS and CELL DEATH by functioning as an oxidative stress sensor and redox-sensitive MOLECULAR CHAPERONE and PROTEASE. Mutations in the PARK7 gene are associated with autosomal-recessive, early-onset PARKINSON DISEASE.;

MeSH synonym : DJ-1, Protein Deglycase; DJ-1-PARK7 Protein; DJ 1 PARK7 Protein; DJ-1 Protein; DJ 1 Protein; Parkinson Protein 7; DJ1 Protein; PARK7 Protein; Parkinsonism Associated Deglycase; Deglycase, Parkinsonism Associated;

Registry Number MeSH : EC 3.1.2.-;

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Keyword's position in hierarchy(ies) : arborescence

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A protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, releasing repaired proteins and lactate or glycolate. It deglycates CYSTEINE, ARGININE and LYSINE residues to reactivate proteins by reversing glycation and prevent the formation of ADVANCED GLYCATION END PRODUCTS. It protects cells against OXIDATIVE STRESS and CELL DEATH by functioning as an oxidative stress sensor and redox-sensitive MOLECULAR CHAPERONE and PROTEASE. Mutations in the PARK7 gene are associated with autosomal-recessive, early-onset PARKINSON DISEASE.

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05/07/2025


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