MeSH definition : A protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and
proteins, releasing repaired proteins and lactate or glycolate. It deglycates CYSTEINE,
ARGININE and LYSINE residues to reactivate proteins by reversing glycation and prevent
the formation of ADVANCED GLYCATION END PRODUCTS. It protects cells against OXIDATIVE
STRESS and CELL DEATH by functioning as an oxidative stress sensor and redox-sensitive
MOLECULAR CHAPERONE and PROTEASE. Mutations in the PARK7 gene are associated with
autosomal-recessive, early-onset PARKINSON DISEASE.;
MeSH synonym : DJ-1, Protein Deglycase; DJ-1-PARK7 Protein; DJ 1 PARK7 Protein; DJ-1 Protein; DJ 1 Protein; Parkinson Protein 7; DJ1 Protein; PARK7 Protein; Parkinsonism Associated Deglycase; Deglycase, Parkinsonism Associated;
A protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and
proteins, releasing repaired proteins and lactate or glycolate. It deglycates CYSTEINE,
ARGININE and LYSINE residues to reactivate proteins by reversing glycation and prevent
the formation of ADVANCED GLYCATION END PRODUCTS. It protects cells against OXIDATIVE
STRESS and CELL DEATH by functioning as an oxidative stress sensor and redox-sensitive
MOLECULAR CHAPERONE and PROTEASE. Mutations in the PARK7 gene are associated with
autosomal-recessive, early-onset PARKINSON DISEASE.