AlkB Homolog 4, Lysine Demethylase

Preferred Label : AlkB Homolog 4, Lysine Demethylase;

MeSH definition : A dioxygenase and alkylation repair homolog that mediates demethylation of ACTIN monomethylated at 'Lys-84' (K84me1). Demethylation of actin LYSINE 84 (K84me1) is required for maintaining actin and MYOSIN dynamics to support normal cleavage furrow ingression during CYTOKINESIS and CELL MIGRATION. It may also be involved in transcription regulation.;

MeSH synonym : Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 4; Alpha Ketoglutarate Dependent Dioxygenase Alkb Homolog 4; Alkylated DNA Repair Protein AlkB Homolog 4;

Registry Number MeSH : EC 1.14.11.27;

UNII : EC 1.14.11.27;

Details

Origin ID

D000071501;

UMLS CUI

C4255105;

Allowable qualifiers
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Automatic exact mappings (from CISMeF team)
- Alkb homolog 4, lysine demethylase [OMIM gene]
- alkB homolog 4, lysine demethylase [HGNC gene]
Record concept(s)
- AlkB Homolog 4, Lysine Demethylase [MeSH concept]
Related MeSH Supplementary Concept(s)
- ALKBH4 protein, human [MeSH Supplementary Concept]
- ALKBH4 protein, mouse [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

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