MeSH definition : An ADAMTS protease similar to ADAMTS5 PROTEIN. It contains a single C-terminal thrombospondin
(TS) motif and cleaves AGGRECAN in CARTILAGE. It may also be involved in the destruction
of aggrecan in ARTHRITIS.;
MeSH synonym : Aggrecanase-1; Aggrecanase 1; A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4 Protein; ADAMTS-4 Protein; ADAMTS 4 Protein;
An ADAMTS protease similar to ADAMTS5 PROTEIN. It contains a single C-terminal thrombospondin
(TS) motif and cleaves AGGRECAN in CARTILAGE. It may also be involved in the destruction
of aggrecan in ARTHRITIS.