ADAMTS5 Protein

Preferred Label : ADAMTS5 Protein;

MeSH definition : An ADAMTS protease that contains two C-terminal thrombospondin (TS) motifs. It functions primarily as an aggrecanase, cleaving AGGRECAN in CARTILAGE, and may be involved in the destruction of aggrecan in ARTHRITIS.;

MeSH synonym : A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5 Protein; ADAMTS11 Protein; Aggrecanase-2; Aggrecanase 2; ADAMTS-5 Protein; ADAMTS 5 Protein; ADAMTS5 Protease;

Registry Number MeSH : EC 3.4.24.-;

Details

Origin ID

D000071116;

UMLS CUI

C4255122;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- A disintegrin-like and metalloproteinase with thrombospondin type 1 motif, 5 [OMIM gene]
- ADAM metallopeptidase with thrombospondin type 1 motif 5 [HGNC gene]
Record concept(s)
- ADAMTS5 Protein [MeSH concept]
Related MeSH Supplementary Concept(s)
- ADAMTS5 protein, human [MeSH Supplementary Concept]
- Adamts5 protein, mouse [MeSH Supplementary Concept]
- Adamts5 protein, rat [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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