MutL Protein Homolog 1

Preferred Label : MutL Protein Homolog 1;

MeSH definition : Eukaryotic homolog of the bacterial MutL DNA MISMATCH REPAIR protein. It heterodimerizes with MISMATCH REPAIR ENDONUCLEASE PMS2 to form MutL alpha, which is recruited to DNA mismatch sites by the MUTS DNA MISMATCH-BINDING PROTEIN. Mutations in the human MLH1 gene are associated with COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS.;

MeSH synonym : MLH1 Protein; Colon Cancer, Nonpolyposis Type 2 Protein; MutL Homolog 1; COCA2 Protein;

Registry Number MeSH : EC 3.6.1.3;

UNII : EC 3.6.1.3;

Details

Origin ID

D000070957;

UMLS CUI

C4255065;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- DNA Mismatch Repair Protein Mlh1 [NCIt concept]
- MutL Homolog 1 Measurement [NCIt concept]
- mutL homolog 1 [ORDO Gene]
- mutL homolog 1 [HGNC gene]
Record concept(s)
- MutL Protein Homolog 1 [MeSH concept]
Related MeSH Supplementary Concept(s)
- MLH1 protein, S cerevisiae [MeSH Supplementary Concept]
- MLH1 protein, arabidopsis [MeSH Supplementary Concept]
- MLH1 protein, human [MeSH Supplementary Concept]
- Mlh1 protein, mouse [MeSH Supplementary Concept]
- Mlh1 protein, rat [MeSH Supplementary Concept]
- Mlh1 protein, zebrafish [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- DNA mismatch repair protein Mlh1 [LOINC component]
- DNA mismatch repair protein Mlh1 (substance) [SNOMED CT concept]

Keyword's position in hierarchy(ies) :

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