Preferred Label : MutL Proteins;
MeSH definition : DNA repair proteins that include the bacterial MutL protein and its eukaryotic homologs.
They consist of a conserved N-terminal region with weak ATPase activity, an endonuclease
motif, and a C-terminal domain that forms MutL homodimers or heterodimers between
MLH1 and the PMS1, MISMATCH REPAIR ENDONUCLEASE PMS2; or MLH3 proteins. These complexes
function in DNA repair pathways, primarily DNA MISMATCH REPAIR, where MutL/MLH1 and
the MUTS DNA MISMATCH-BINDING PROTEIN are targeted to damaged DNA.;
DeCS synonym : MutL Homologs;
Registry Number MeSH : EC 3.6.1.3;
UNII : EC 3.6.1.3;
Origin ID : D000070956;
UMLS CUI : C4277738;
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DNA repair proteins that include the bacterial MutL protein and its eukaryotic homologs.
They consist of a conserved N-terminal region with weak ATPase activity, an endonuclease
motif, and a C-terminal domain that forms MutL homodimers or heterodimers between
MLH1 and the PMS1, MISMATCH REPAIR ENDONUCLEASE PMS2; or MLH3 proteins. These complexes
function in DNA repair pathways, primarily DNA MISMATCH REPAIR, where MutL/MLH1 and
the MUTS DNA MISMATCH-BINDING PROTEIN are targeted to damaged DNA.
