" /> Blood group, vel system - CISMeF





Preferred Label : Blood group, vel system;

Symbol : VEL;

CISMeF acronym : VEL;

Type : Phenotype, molecular basis known;

Included titles and symbols : Vel-null phenotype;

Description : The Vel blood group system is defined by the presence of the Vel antigen on red blood cells. Vel is a high frequency antigen that shows variable strength, ranging from strong to weak. The rare Vel-negative blood type is inherited as an autosomal recessive trait and is typically unveiled when Vel-negative individuals develop anti-Vel antibodies after transfusion or pregnancy; Vel alloantibodies are never 'naturally occurring.' Individuals with anti-Vel antibodies may develop severe acute hemolytic transfusion reactions when transfused with Vel-positive blood. Individuals negative for the Vel antigen are rare and are required for the safe transfusion of patients with antibodies to Vel (summary by Daniels, 2002; Storry et al., 2013; Cvejic et al., 2013; Ballif et al., 2013).;

Inheritance : Autosomal recessive;

Molecular basis : Caused by mutation in the small integral membrane protein 1 gene (SMIM1, 615242.0001);

Prefixed ID : #615264;

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Keyword's position in hierarchy(ies) : arborescence

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01/05/2025


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