Preferred Label : Blood group, globoside system;
Symbol : GLOB;
CISMeF acronym : GLOB;
Type : Phenotype, molecular basis known;
Description : The P antigen, globoside-4 (Gb4), is a prominent glycosphingolipid on human erythrocytes
(summary by Okajima et al., 2000). P-related IgG and IgM antibodies are implicated
in hemolytic transfusion reactions, hemolytic disease of the newborn, and spontaneous
abortion (see 614389) (summary by Thuresson et al., 2011). Anti-P antibodies are also
implicated in paroxysmal cold hemoglobinuria (PCH), a syndrome often seen in children
after viral infection. In PCH, anti-P is also known as the Donath-Landsteiner antibody
(Cantin and Lyonnais, 1983; Spitalnik and Spitalnik, 1995).;
Prefixed ID : #615021;
Origin ID : 615021;
UMLS CUI : C3539121;
Automatic exact mappings (from CISMeF team)
- Genes related to phenotype
- Semantic type(s)
