Preferred Label : Blood group, chido/rodgers system;
Type : Phenotype, molecular basis known;
Alternative titles and symbols : Chido/rodgers blood group system;
Description : The blood groups Chido (Ch) and Rodgers (Rg) are epitopes on the C4 protein, and polymorphisms
associated with these epitopes may lead to the formation of antibodies to the Ch or
Rg antigens in transfused patients. Identification of anti-Ch or anti-Rg is based
on antibody neutralization with plasma from Ch-positive or Rg-positive individuals
and lack of reactivity with qualified Ch-negative or Rg-negative red blood cells.
The C4 protein occurs in 2 forms, C4A and C4B, which are encoded by 2 closely linked
genes. C4A and C4B are expressed as single-chain precursors of 1,744 amino acids that
are nearly identical, with amino acids differences at residues 1101 to 1106 distinguishing
C4A from C4B. C4A and C4B are also distinguished by their expression of either the
Ch antigen or the Rg antigen at residues 1188 to 1191, where the Ch1 epitope has ADLR
and the Rg1 epitope has VDLL. C4A proteins usually carry the Rg antigens, and C4B
proteins usually carry the Ch antigens, although in some haplotypes these associations
are switched. Nine antigens have been described for the Ch/Rg system: 6 of high prevalence
for Ch, 2 of high prevalence for Rg, and 1 of low prevalence, WH. Eight phenotypes
of the Ch/Rg system have been established, with 88.2% of individuals having the Ch(1,2,3)
Chido phenotype and 95.0% of individuals having the Rg(1,2) Rodgers phenotype (review
by Mougey (2010)).;
Prefixed ID : #614374;
Origin ID : 614374;
UMLS CUI : C1292315;
Currated CISMeF NLP mapping
- Genes related to phenotype
- Semantic type(s)
- UMLS correspondences (same concept)
