Preferred Label : Dengue virus, susceptibility to;
Type : Phenotype, molecular basis known;
Included titles and symbols : Dengue fever, susceptibility to; Dengue fever, protection against; Dengue hemorrhagic fever, susceptibility to; Dengue shock syndrome, susceptibility to;
Description : Dengue virus is a flavivirus belonging to the family Flaviviridae. Its principal vector
is Aedes aegypti, a highly urbanized, daytime-biting mosquito that breeds in stored
water. There are 4 antigenetically variant serotypes of dengue virus, DEN-1 to DEN-4,
and type-specific immunity against one serotype cannot block infection with another
serotype. Disease manifestations following dengue infection range from subclinical
infection to severe and fatal disease, with age, gender, genotype, immunologic status,
and flavivirus infection history of the host all influencing disease severity. Primary
infection is mainly associated with dengue fever (DF). Symptoms of DF typically appear
4 to 7 days after the mosquito bite and include high fever, headache, retroocular
pain, conjunctival changes, and facial flushing. Although primary dengue infections
are mostly recovered, a secondary infection with a different serotype of the virus
leads to the complex condition of dengue hemorrhagic fever (DHF) with plasma leakage
and thrombocytopenia or a more fatal condition, dengue shock syndrome (DSS). High
fever, hemorrhagic phenomenon, hepatomegaly, and circulatory failure are mainly associated
with DHF. Hemorrhages in DHF are seen in skin, subcutaneous tissues, heart, liver,
and gastrointestinal tract. An estimated 50 to 100 million illnesses due to dengue
infection occur annually, including 250,000 to 500,000 cases of DHF and 24,000 deaths.
About 2.5 billion people are estimated to be at risk, particularly those living in
tropical and subtropical areas of Asia and Latin America (reviews by Faheem et al.
(2011), Whitehorn and Simmons (2011), and Guzman et al. (2010)).;
Prefixed ID : #614371;
Origin ID : 614371;
UMLS CUI : C3280582;
Genes related to phenotype
- ORDO concept(s)
- See also inter- (CISMeF)
- Semantic type(s)
