Description : Delayed sleep phase syndrome is a circadian rhythm sleep disorder characterized by
sleep-onset insomnia and difficulty in awakening at the desired time. Patients with
DSPS have chronic difficulty in adjusting their sleep-onset and wake-up times to occupational,
school, and social activities. Although psychosocial and environmental factors sometimes
induce this kind of disorder, most patients with DSPS appear to have an abnormal circadian
pacemaker and/or an abnormal entrainment system (summary by Hohjoh et al., 2003).;
Inheritance : Autosomal dominant;
Molecular basis : Susceptibility conferred by mutation in the cryptochrome 1 gene (CRY1, 601933.0001);
Currated CISMeF NLP mapping