Preferred Label : Aspergillosis, susceptibility to;
Type : Phenotype, molecular basis known;
Description : Aspergillus species are ubiquitous in nature and cause a wide spectrum of diseases,
including saprophytic colonization of existing cavities (aspergilloma), allergic asthma,
hypersensitivity pneumonitis, allergic bronchopulmonary aspergillosis, and disseminated
disease associated with high mortality rates in patients with hematologic malignancies
and recipients of solid organs and stem cell transplantations. Immunocompetent and
nonatopic individuals are relatively resistant to infection, and disease occurs in
the setting of host damage. Association of persistent inflammation with intractable
infection is common in nonneutropenic patients after hematopoietic stem cell transplantation,
as well as in allergic fungal diseases. The pathophysiology underlying Aspergillus
infection highlights the bipolar nature of the inflammatory process in infection,
in which early inflammation prevents or limits infection, but an uncontrolled response
may oppose disease eradication (summary by Cunha et al., 2010). For information on
familial occurrence of allergic bronchopulmonary aspergillosis, see 103920.;
Prefixed ID : #614079;
Origin ID : 614079;
UMLS CUI : C3279774;
Automatic exact mappings (from CISMeF team)
- Genes related to phenotype
- ORDO concept(s)
- Semantic type(s)
