Preferred Label : Blood group, cromer system;
Symbol : CROM;
CISMeF acronym : CROM;
Type : Phenotype, molecular basis known;
Alternative titles and symbols : Cromer blood group system;
Description : The Cromer blood group system (CROM) consists of 12 high-prevalence and 3 low-prevalence
antigens that reside on decay-accelerating factor (DAF, or CD55; 125240), a regulator
of complement activation. Nearly all Cromer antigens result from SNPs in the DAF gene.
The red blood cells (RBCs) of people with the Cromer-null phenotype, Inab, lack DAF
but do not appear to show increased susceptibility to hemolysis. Antibodies to Cromer
antigens are rarely encountered, although evidence suggests that the antibodies may
cause accelerated destruction of transfused RBCs. Cromer system antibodies are not
associated with hemolytic disease of the newborn, because placenta is a rich source
of fetally derived DAF, which is thought to absorb the antibodies (review by Storry
et al., 2010).;
Inheritance : Autosomal recessive;
Molecular basis : Caused by mutation in the CD55 antigen gene (CD55, 125240.0001);
Neoplasia : Gastrointestinal tumors (in some patients);
Prefixed ID : #613793;
Origin ID : 613793;
UMLS CUI : C1292305;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Genes related to phenotype
- HPO term(s)
- Semantic type(s)
- UMLS correspondences (same concept)
