Preferred Label : Tuberculin skin test reactivity, absence of;
CISMeF acronym : TST1;
Type : Phenotype or locus, molecular basis unknown;
Alternative titles and symbols : Tst reactivity, absence of; TST1;
Description : For background information on susceptibility and resistance to Mycobacterium tuberculosis,
see 607948. The tuberculin skin test (TST), or Mantoux test, measures induration of
the skin after intradermal inoculation of M. tuberculosis purified protein derivative
and thereby detects M. tuberculosis-infected and -noninfected persons. The TST triggers
a classical T cell-mediated delayed-type hypersensitivity reaction against mycobacterial
antigens. About 20% of individuals living in areas hyperendemic for tuberculosis show
persistent absence of TST reactivity, suggesting T cell-independent resistance to
M. tuberculosis infection. Genetic epidemiologic studies in endemic areas have suggested
that host genetic factors contribute to resistance to M. tuberculosis infection and
to the immune reactions underlying TST reactivity (summary by Cobat et al., 2009).;
Prefixed ID : %613636;
Origin ID : 613636;
UMLS CUI : C3150892;
Automatic exact mappings (from CISMeF team)
- False automatic mappings
- Semantic type(s)
