Alternative titles and symbols : Hyperfibrinolysis due to pai1 deficiency;
Description : Plasminogen inhibitor-1 deficiency is a rare autosomal recessive hematologic disorder
characterized by increased bleeding after trauma, injury, or surgery. Affected females
have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood
clots due to deficiency of PAI1, which inhibits tissue (PLAT; 173370) and urinary
(PLAU; 191840) activators of plasminogen (PLG; 173350) (review by Mehta and Shapiro,
2008).;