Preferred Label : Age-related hearing impairment 1;
Symbol : ARHI1;
CISMeF acronym : ARHI1;
Type : Phenotype or locus, molecular basis unknown;
Alternative titles and symbols : Presbycusis 1;
Description : Age-related hearing impairment (ARHI), or presbycusis, is the progressive bilaterally
symmetric deterioration of hearing ability that occurs with aging. Studies of the
cochlea in many animal species and of the histopathology of human temporal bones have
shown that stria vascularis volumes and spiral ganglion cell, inner hair cell, and
outer hair cell populations, as well as many other cochlear cell types and structures,
undergo age-related degeneration. Environmental risk factors for ARHI include noise
exposure, smoking, ototoxic medication, and cardiovascular disease. Heritability estimates
vary between 0.25 and 0.75 depending on, among other factors, study design (family
vs twins), age range of the study population, and the phenotype studied (Huyghe et
al., 2008).;
Prefixed ID : %612448;
Origin ID : 612448;
UMLS CUI : C2676230;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
