Preferred Label : Hepatitis b virus, susceptibility to;
Type : Phenotype, molecular basis known;
Alternative titles and symbols : Hbv, susceptibility to;
Included titles and symbols : Hepatitis b virus, resistance to; Hbv, resistance to;
Description : HBV is a DNA virus that enters the liver via the bloodstream, and replication occurs
only in liver tissue. Transmission occurs by percutaneous or mucosal exposure to infected
blood or other body fluids. Approximately one third of all cases of cirrhosis and
half of all cases of hepatocellular carcinoma (HCC; 114550) can be attributed to chronic
HBV infection. Worldwide, 2 billion people have been infected with HBV, 360 million
have chronic infection, and 600,000 die each year from HBV-related liver disease or
HCC. However, there is marked geographic variability in HBV prevalence, with chronic
infection affecting less than 2% of the populations of North America and western and
northern Europe; between 2 and 7% of the populations of eastern and central Europe,
the Amazon basin, the Middle East, and the Indian subcontinent; and more than 8% of
the populations of Asia, sub-Saharan Africa, and the Pacific (Seeff and Hoofnagle,
2006; Shepard et al., 2006).;
Prefixed ID : #610424;
Origin ID : 610424;
UMLS CUI : C1864880;
Genes related to phenotype
- Semantic type(s)
