Type : Phenotype or locus, molecular basis unknown;
Alternative titles and symbols : BPEO; Bipolar affective disorder, early-onset;
Description : For a phenotypic description and a discussion of genetic heterogeneity of bipolar
disorder, see 125480. Bipolar disorder (BPAD) is a severe psychiatric disorder that
manifests with alternating episodes of mania and depression. Age at onset (AAO) is
a potential clinical marker of genetic heterogeneity in BPAD. Lin et al. (2005) sought
to incorporate AAO as a covariate in linkage analyses of;