Preferred Label : Hepatitis C virus, susceptibility to;
Type : Phenotype, molecular basis known;
Alternative titles and symbols : Hcv, susceptibility to;
Included titles and symbols : Hepatitis C virus, resistance to; Hcv, resistance to; Hepatitis C virus infection, response to therapy of;
Description : HCV, which is principally transmitted by blood, infects about 3% of the world's population.
HCV infection causes acute hepatitis, which is self-resolving in 20 to 50% of cases
but does not confer permanent immunity. In 50 to 80% of cases, HCV infection becomes
chronic and results in chronic hepatitis, cirrhosis, and hepatocellular carcinoma.
As a result, HCV infection is a leading killer worldwide and the most common cause
of liver failure in the U.S. HCV is opportunistic in individuals infected with human
immunodeficiency virus (HIV; see 609423), approximately 25% of whom are coinfected
with HCV. HCV infection is also associated with cryoglobulinemia (see 123550), a B-lymphocyte
proliferative disorder (Pawlotsky, 2004; Chisari (2005); Pileri et al., 1998).;
Prefixed ID : #609532;
Origin ID : 609532;
UMLS CUI : C1835407;
Automatic exact mappings (from CISMeF team)
- Genes related to phenotype
- ORDO concept(s)
- Semantic type(s)
