Mycobacterium tuberculosis, susceptibility to

Preferred Label : Mycobacterium tuberculosis, susceptibility to;

Type : Phenotype, molecular basis known;

Included titles and symbols : Mycobacterium tuberculosis, protection against;

Description : Mycobacterium tuberculosis latently infects approximately one-third of humanity and is comparable only to human immunodeficiency virus (HIV; see 609423) as a leading infectious cause of mortality worldwide. Obstacles for controlling TB infection include lengthy treatment regimens of 6 to 9 months, drug resistance, lack of a highly efficacious vaccine, and incomplete understanding of the factors that control infectivity and disease progression. Although only 10% of individuals infected with M. tuberculosis develop active disease, the immune responses associated with TB susceptibility or resistance are not known. In addition, it is not known why some individuals have disseminated TB that spreads to the meninges and central nervous system, while most people have localized disease in the lungs. A number of studies suggest that host genetic factors influence susceptibility and resistance to TB (review by Berrington and Hawn, 2007).;

Prefixed ID : #607948;

Details

Origin ID

607948;

UMLS CUI

C1834752;

Automatic exact mappings (from CISMeF team)
- Tuberculosis [ORDO Disease]
Genes related to phenotype
- Cd209 antigen [OMIM gene]
- Cytokine-inducible sh2-containing protein [OMIM gene]
- Immunity-related gtpase family, M [OMIM gene]
- Interferon, gamma [OMIM gene]
- Interferon-gamma receptor 1 [OMIM gene]
- Nuclear body protein sp110 [OMIM gene]
- Solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 [OMIM gene]
- Tir domain-containing adaptor protein [OMIM gene]
- Toll-like receptor 2 [OMIM gene]
ORDO concept(s)
- Tuberculosis [ORDO Disease]
Semantic type(s)
- Finding [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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