Preferred Label : Anxiety;
Type : Phenotype, molecular basis known;
Included titles and symbols : Harm avoidance;
Description : Human personality is shaped by genetic and environmental factors, and evidence suggests
that the genetic component is highly complex, polygenic, and epistatic. Genetic factors
are thought to contribute to 40 to 60% of trait variance. Molecular genetics has tried
to identify specific genes for quantitative traits, called quantitative trait loci
(QTLs). The QTL concept suggests that complex personality traits or dimensions are
not attributable to single genes, but to multiple interacting genes (Reif and Lesch,
2003). Fullerton et al. (2003) stated that psychologists were in agreement that the
wide variation in human personalities can be explained by a small number of personality
factors, including neuroticism (a measure of emotional stability), which manifests
at one extreme as anxiety, depression, moodiness, low self-esteem, and diffidence.
They cited a number of studies that had described a relationship between high scores
on measures of neuroticism and major depressive disorder. They also noted that theoretical
studies had suggested that large samples of randomly ascertained sibs could be used
to ascertain phenotypically extreme individuals and thereby increase power to detect
genetic linkage in complex traits. See also panic disorder (PAND1; 167870), which
is a subtype of anxiety disorder.;
Prefixed ID : #607834;
Origin ID : 607834;
UMLS CUI : C0003467;
Automatic exact mappings (from CISMeF team)
- anxiety [Blood Transfusion thesaurus concept]
- Currated CISMeF NLP mapping
- DO Cross reference
- Genes related to phenotype
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
