Nail disorder, nonsyndromic congenital, 8 - CISMeF
Nail disorder, nonsyndromic congenital, 8OMIM Phenotype
Preferred Label : Nail disorder, nonsyndromic congenital, 8;
Symbol : NDNC8;
CISMeF acronym : NDNC8;
Type : Phenotype, molecular basis known;
Alternative titles and symbols : Toenail dystrophy, isolated;
Description : This form of isolated toenail dystrophy has been found to segregate as an autosomal
dominant trait in families in which another member has the autosomal recessive skin
disorder dystrophic epidermolysis bullosa (226600) or transient bullous dermolysis
of the newborn (131705), the features of which include dystrophic nails. The nail
changes in isolated toenail dystrophy are most severe in the great toes and consist
of the nail plate being buried in the nail bed with a deformed and narrow free edge
(summary by Sato-Matsumura et al., 2002). This form of toenail dystrophy is referred
to here as nonsyndromic congenital nail disorder-8 (NDNC8). For a list of other nonsyndromic
congenital nail disorders and a discussion of genetic heterogeneity, see NDNC1 (161050).;
Inheritance : Autosomal dominant;
Molecular basis : Caused by mutation in the alpha-1 type VII collagen gene (COL7A1, 120120.0014);