Description : Hereditary spastic paraplegia (SPG) is characterized by progressive weakness and spasticity
of the lower limbs due to degeneration of corticospinal axons. There is considerable
genetic heterogeneity. Inheritance is most often autosomal dominant (see 182600),
but X-linked (see 312920) and autosomal recessive (see 270800) forms occur. SPG7 shows
phenotypic variability between families. Some cases are pure, whereas other are complicated
with additional neurologic features (Warnecke et al., 2007).;