Alternative titles and symbols : Vascular malformation osseous; VMOS; Hemangioma, intraosseous;
Description : Primary intraosseous vascular anomaly, previously called intraosseous hemangioma,
is a rare malformation that usually involves the vertebral column and the skull. The
most commonly affected bones in the skull are the mandible and the maxilla, and life-threatening
bleeding after a simple tooth extraction is frequent (Vargel et al., 2002).;
Inheritance : Autosomal recessive;
Molecular basis : Caused by mutation in the engulfment and cell motility gene-2 gene (ELMO2, 606421.0001);
Laboratory abnormalities : Elevated alkaline phosphatase; Elevated lactate dehydrogenase (in some patients);