Preferred Label : Anorexia nervosa, susceptibility to;
Symbol : ANON;
CISMeF acronym : AN; ANON; ANON1;
Type : Phenotype or locus, molecular basis unknown;
Alternative titles and symbols : AN;
Included titles and symbols : Anorexia nervosa, susceptibility to, 1; ANON1;
Description : Eating disorders such as anorexia nervosa are complex disorders that can be influenced
by many genes. One locus for susceptibility to anorexia nervosa (ANON1) has been mapped
to chromosome 1p. Susceptibility to anorexia (ANON2; 610269) has also been associated
with polymorphisms in the BDNF gene (113505) on chromosome 11. Eating disorders are
characterized by severe disturbances in eating behavior that typically have onset
during late adolescence and early adulthood. Three major types are recognized: anorexia
nervosa (AN), bulimia nervosa (BN; 607499), and eating disorder not otherwise specified
(EDNOS). AN is characterized by obsessive fear of weight gain, severely restricted
eating, and low body weight. In women, AN has the highest mortality among the psychiatric
disorders (Sullivan, 1995). AN is divided into 2 clinical subtypes, restricting anorexia
nervosa (RAN) and binge-eating/purging anorexia nervosa (BPAN). BN can occur at any
body weight and is characterized by binge-eating and compensatory weight-loss behaviors.
Family studies have indicated an increased prevalence of eating disorders in relatives
of probands with AN (Lilenfeld et al., 1998), and twin studies (Holland et al., 1984;
Wade et al., 2000) have estimated concordance rates for monozygotic twins with AN
to be 52 to 56%, whereas concordance rates for dizygotic twins with AN have been estimated
to be 5 to 11% (Grice et al., 2002).;
Prefixed ID : %606788;
Origin ID : 606788;
UMLS CUI : C1847492;
Automatic exact mappings (from CISMeF team)
- False automatic mappings
- Genes related to phenotype
- Semantic type(s)
