" /> Melanoma-pancreatic cancer syndrome - CISMeF





Preferred Label : Melanoma-pancreatic cancer syndrome;

CISMeF acronym : FAMMMPC;

Type : Phenotype, molecular basis known;

Alternative titles and symbols : FAMMMPC; Familial atypical multiple mole melanoma-pancreatic carcinoma syndrome;

Description : Melanoma-pancreatic cancer syndrome is an inherited cancer predisposition syndrome in which mutation carriers have an increased risk of developing malignant melanoma and/or pancreatic cancer. Mutation carriers within families may develop either or both types of cancer (summary by Harinck et al., 2012). For background and phenotypic information on malignant melanoma and pancreatic cancer, see 155600 and 260350, respectively.;

Inheritance : Autosomal dominant;

Molecular basis : Caused by mutation in cyclin-dependent kinase inhibitor 2A (CDKN2A, 600160.0003);

Neoplasia : Pancreatic adenocarcinoma; Pancreatic squamous cell carcinoma; Melanoma; Oropharyngeal squamous cell carcinoma; Sarcoma;

Prefixed ID : #606719;

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28/07/2025


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