Alzheimer disease 6

Preferred Label : Alzheimer disease 6;

CISMeF acronym : AD6;

Type : Phenotype or locus, molecular basis unknown;

Alternative titles and symbols : Alzheimer disease 6, late-onset; AD6;

Included titles and symbols : Plasma beta-amyloid-42 level quantitative trait locus;

Description : For a general phenotypic description and a discussion of genetic heterogeneity of Alzheimer disease (AD), see 104300. Alzheimer disease (AD) is a neurodegenerative disorder characterized by subtle onset of memory loss followed by a slowly progressive dementia. The great majority of AD cases are of late onset (LOAD) after age 65 years. LOAD shows complex, nonmendelian patterns of inheritance, and most likely results from the combined effects of variation in a number of genes as well as from environmental factors (summary by Grupe et al., 2006). The Alzheimer disease-6 (AD6) designation refers to a susceptibility locus on chromosome 10q. Although significant associations with several candidate genes on chromosome 10 have been reported, these findings have not been consistently replicated, and they remain controversial (Grupe et al., 2006).;

Prefixed ID : %605526;

Details

Origin ID

605526;

UMLS CUI

C1854187;

Currated CISMeF NLP mapping
- Alzheimer's disease 6 [DO Concept]
- alzheimer disease 6 [MeSH concept]
- alzheimer disease 6 [MeSH Supplementary Concept]
DO Cross reference
- Alzheimer's disease 6 [DO Concept]
False automatic mappings
- cloricromen [MeSH Supplementary Concept]
ORDO concept(s)
- Early-onset autosomal dominant Alzheimer disease [ORDO Disease]
Semantic type(s)
- Disease or Syndrome [UMLS semantic type]
UMLS correspondences (same concept)
- Alzheimer's disease 6 [DO Concept]
- alzheimer disease 6 [MeSH Supplementary Concept]
- alzheimer disease 6 [MeSH concept]

Keyword's position in hierarchy(ies) :

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