" /> Thyroid carcinoma, nonmedullary, with or without cell oxyphilia - CISMeF





Preferred Label : Thyroid carcinoma, nonmedullary, with or without cell oxyphilia;

CISMeF acronym : TCO; TCO1;

Type : Phenotype or locus, molecular basis unknown;

Alternative titles and symbols : TCO; TCO1;

Description : The familial form of nonmedullary thyroid carcinoma (FNMTC) is a complex genetic disorder characterized by multifocal neoplasia and a higher degree of aggressiveness than its sporadic counterpart. For background and phenotypic information on NMTC, see 188550. One peculiar form of thyroid tumors is characterized by the presence of cell oxyphilia. Oxophil cells are found in a minority of thyroid tumors, either benign or malignant. These cells show a large volume of granular eosinophilic cytoplasm and are very rich in mitochondria. The familial occurrence of thyroid tumors with cell oxyphilia was reported by Katoh et al. (1998). Canzian et al. (1998) reported such a family with affected members in 3 generations and by linkage analysis mapped the gene to 19p13.;

Prefixed ID : %603386;

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03/05/2025


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