Hyperthyroidism, familial gestational

Preferred Label : Hyperthyroidism, familial gestational;

Type : Phenotype, molecular basis known;

Description : Some degree of stimulation of the thyroid gland by chorionic gonadotropin (see 118860) is common during early pregnancy. When serum chorionic gonadotropin concentrations are abnormally high, e.g., in women with molar pregnancies (231090), overt hyperthyroidism may ensue. The pathophysiologic mechanism appears to be promiscuous stimulation of the thyrotropin receptor by the excess chorionic gonadotropin. The explanation for this stimulation is the close structural relations between chorionic gonadotropin and thyrotropin and between their receptors (Grossmann et al., 1997).;

Prefixed ID : #603373;

Details

Origin ID

603373;

UMLS CUI

C1863959;

Currated CISMeF NLP mapping
- Familial gestational hyperthyroidism [ICD-11 More detail]
- Familial gestational hyperthyroidism [ORDO Disease]
- Familial gestational hyperthyroidism (disorder) [SNOMED CT concept]
- hyperthyroidism, familial gestational [MeSH concept]
- hyperthyroidism, familial gestational [MeSH Supplementary Concept]
DO Cross reference
- hyperthyroidism [DO Concept]
Genes related to phenotype
- Thyroid-stimulating hormone receptor [OMIM gene]
HPO term(s)
- Autosomal dominant inheritance [HPO term]
- Decreased thyroid-stimulating hormone level [HPO term]
- Hyperemesis gravidarum [HPO term]
- Hyperthyroidism [HPO term]
- Increased circulating T4 level [HPO term]
- Tachycardia [HPO term]
ORDO concept(s)
- Familial gestational hyperthyroidism [ORDO Disease]
Semantic type(s)
- Disease or Syndrome [UMLS semantic type]
UMLS correspondences (same concept)
- Familial gestational hyperthyroidism [ORDO Disease]
- Familial gestational hyperthyroidism [ICD-11 More detail]
- Familial gestational hyperthyroidism (disorder) [SNOMED CT concept]
- hyperthyroidism, familial gestational [MeSH Supplementary Concept]
- hyperthyroidism, familial gestational [MeSH concept]

Keyword's position in hierarchy(ies) :

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