Type : Phenotype or locus, molecular basis unknown;
Description : Astigmatism (from the Greek 'a' meaning absence and 'stigma' meaning point) is a condition
in which the parallel rays of light entering the eye through the refractive media
are not focused on a single point. Both corneal and noncorneal factors contribute
to refractive astigmatism. Corneal astigmatism is mainly the result of an aspheric
anterior surface of the cornea, which can be measured readily by means of a keratometer;
in a small fraction of cases (approximately 1 in 10) the effect is neutralized by
the back surface. The curvature of the back surface of the cornea is not considered
in most studies, because it is more difficult to measure; moreover, in the case of
severe corneal astigmatism, there is evidence that both surfaces have the same configuration.
Noncorneal factors are errors in the curvature of the 2 surfaces of the crystalline
lens, irregularity in the refractive index of the lens, and an eccentric lens position.
Since the cornea is the dominant component of the eye's refracting system, a highly
astigmatic cornea is likely to result in a similarly astigmatic ocular refraction
(summary by Clementi et al., 1998).;