" /> Glomerulopathy with fibronectin deposits 2 - CISMeF





Preferred Label : Glomerulopathy with fibronectin deposits 2;

Symbol : GFND2;

CISMeF acronym : GFND2;

Type : Phenotype, molecular basis known;

Alternative titles and symbols : Glomerular nephritis, familial, with fibronectin deposits; Fibronectin glomerulopathy;

Description : Glomerulopathy with fibronectin deposits is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life. Pathologic examination shows enlarged glomeruli with mesangial and subendothelial fibrillary deposits that show strong immunoreactivity to fibronectin (Castelletti et al., 2008). For a discussion of genetic heterogeneity of GFND, see 137950.;

Inheritance : Autosomal dominant;

Molecular basis : Caused by mutation in the fibronectin 1 gene (FN1, 135600.0001);

Prefixed ID : #601894;

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02/05/2025


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