Preferred Label : Stroke, ischemic;
Type : Phenotype, molecular basis known;
Alternative titles and symbols : Cerebral infarction; Cerebrovascular accident;
Description : A stroke is an acute neurologic event leading to death of neural tissue of the brain
and resulting in loss of motor, sensory and/or cognitive function. It is said to be
the third leading cause of death in the United States. Gunel and Lifton (1996) noted
that about 20% of strokes are hemorrhagic, resulting in bleeding into the brain. Ischemic
strokes, resulting from vascular occlusion, account for the majority of strokes. Bersano
et al. (2008) reviewed genetic polymorphisms that have been implicated in the development
of stroke. Candidate genes include those involved in hemostasis (see, e.g., F5; 612309),
the renin-angiotensin-aldosterone system (see, e.g., ACE; 106180), homocysteine (see,
e.g., MTHFR; 607093), and lipoprotein metabolism (see, e.g., APOE; 107741). See also
hemorrhagic stroke, or intracerebral hemorrhage (ICH; 614519).;
Inheritance : Multifactorial predisposition;
Prefixed ID : #601367;
Origin ID : 601367;
UMLS CUI : C0948008;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- DO Cross reference
- False automatic mappings
- Genes related to phenotype
- HPO term(s)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
