Asthma, susceptibility to

Preferred Label : Asthma, susceptibility to;

Type : Phenotype, molecular basis known;

Alternative titles and symbols : Asthma, bronchial; Asthma-related traits, susceptibility to;

Included titles and symbols : Asthma, protection against; Asthma, diminished response to antileukotriene treatment in;

Description : Bronchial asthma is the most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, and dyspnea; bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test; serum IgE levels; atopy; and atopic dermatitis (Laitinen et al., 2001; Illig and Wjst, 2002; Pillai et al., 2006). See 147050 for information on the asthma-associated phenotype atopy.;

Inheritance : Autosomal dominant vs. multifactorial;

Prefixed ID : #600807;

Details

Origin ID

600807;

UMLS CUI

C1869116;

Automatic exact mappings (from CISMeF team)
- Asthma [HPO term]
- Asthma [MedDRA Preferred Term]
- Asthma (disorder) [SNOMED CT concept]
- Asthma bronchial [MedDRA LLT]
- Bronchial asthma [MedDRA LLT]
- asthma [MedlinePlus Topic]
DO Cross reference
- asthma [DO Concept]
Genes related to phenotype
- Arachidonate 5-lipoxygenase [OMIM gene]
- Chemokine, CC motif, ligand 11 [OMIM gene]
- Histamine n-methyltransferase [OMIM gene]
- Interleukin 13 [OMIM gene]
- Mucin 7, salivary [OMIM gene]
- Phospholipase a2, group VII [OMIM gene]
- Secretoglobin, family 3a, member 2 [OMIM gene]
- Tumor necrosis factor [OMIM gene]
HPO term(s)
- Asthma [HPO term]
- Autosomal dominant inheritance [HPO term]
- Bronchoconstriction [HPO term]
- Multifactorial inheritance [HPO term]
See also inter- (CISMeF)
- asthma [MeSH Descriptor]
- asthma [Disease (Nov.)]
- asthma [MedlinePlus Topic]
- asthma [MeSH concept]
Semantic type(s)
- Finding [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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