Preferred Label : Helicobacter pylori infection, susceptibility to;
Type : Phenotype, molecular basis known;
Description : Helicobacter pylori is a microaerophilic, gram-negative bacterium that colonizes the
gastric mucosa of approximately 50% of the world's population, and is a primary pathogenic
factor in benign and malignant gastroduodenal disease (Warren and Marshall, 1983;
Blaser and Parsonnet, 1994). Tomb et al. (1997) reported the complete sequence of
the circular genome of H. pylori. The 1,667,867-bp genome contains 1,590 predicted
coding sequences (genes). Sequence analysis of these genes indicated that the organism
has systems for motility, for scavenging iron, and for DNA restriction and modification.
Its survival in acid conditions depends, in part, on its ability to establish a positive
inside-membrane potential in low pH.;
Inheritance : Not determined;
Prefixed ID : #600263;
Origin ID : 600263;
UMLS CUI : C1838332;
Automatic exact mappings (from CISMeF team)
- Genes related to phenotype
- HPO term(s)
- Semantic type(s)
