Type : Phenotype or locus, molecular basis unknown;
Alternative titles and symbols : Microphthalmos, simple, autosomal dominant; Nanophthalmos with high hyperopia and angle-closure glaucoma; Nanophthalmia 1; Nanophthalmos, autosomal dominant;
Description : A locus for autosomal dominant nanophthalmos (NNO1) has been mapped to chromosome
11p. Autosomal dominant nanophthalmos is characterized by a small eye, as indicated
by short axial length, high hyperopia, high lens/eye volume ratio, and a high incidence
of angle-closure glaucoma (summary by Othman et al., 1998). - Genetic Heterogeneity
of Nanophthalmos Another locus for autosomal dominant nanophthalmos (NNO3; 611897)
has been mapped to chromosome 2q11-q14. Autosomal recessive nanophthalmos (NNO2; 609549)
can be caused by mutation in the MFRP gene (606227) on chromosome 11q23.;