" /> Monosomy 7 myelodysplasia and leukemia syndrome 1 - CISMeF





Preferred Label : Monosomy 7 myelodysplasia and leukemia syndrome 1;

Symbol : M7MLS1;

CISMeF acronym : MLSM7;

Type : Phenotype, molecular basis known;

Alternative titles and symbols : MLSM7; Monosomy 7 of bone marrow; Chromosome 7q deletion;

Description : Monosomy 7 or partial deletion of the long arm of chromosome 7 (7q-) is a frequent cytogenetic finding in the bone marrow of patients with myelodysplasia (MDS) and acute myelogenous leukemia (AML). Furthermore, monosomy 7 or 7q- is the most frequent abnormality of karyotype in cases of AML that occur after cytotoxic cancer therapy or occupational exposure to mutagens. The age distribution of de novo cases shows peaks in the first and fifth decades. Monosomy 7 is found in about 5% of de novo and 40% of secondary cases of AML. These findings suggest that loss of certain genes at this region is an important event in the development of myelodysplasia (summary by Shannon et al., 1989).;

Inheritance : ?Autosomal recessive;

Prefixed ID : #252270;

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29/07/2025


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