Monosomy 7 myelodysplasia and leukemia syndrome 1 - CISMeF
Monosomy 7 myelodysplasia and leukemia syndrome 1OMIM Phenotype
Preferred Label : Monosomy 7 myelodysplasia and leukemia syndrome 1;
Symbol : M7MLS1;
CISMeF acronym : MLSM7;
Type : Phenotype, molecular basis known;
Alternative titles and symbols : MLSM7; Monosomy 7 of bone marrow; Chromosome 7q deletion;
Description : Monosomy 7 or partial deletion of the long arm of chromosome 7 (7q-) is a frequent
cytogenetic finding in the bone marrow of patients with myelodysplasia (MDS) and acute
myelogenous leukemia (AML). Furthermore, monosomy 7 or 7q- is the most frequent abnormality
of karyotype in cases of AML that occur after cytotoxic cancer therapy or occupational
exposure to mutagens. The age distribution of de novo cases shows peaks in the first
and fifth decades. Monosomy 7 is found in about 5% of de novo and 40% of secondary
cases of AML. These findings suggest that loss of certain genes at this region is
an important event in the development of myelodysplasia (summary by Shannon et al.,
1989).;