Preferred Label : Intracranial hypertension, idiopathic;
Type : Other, mainly phenotypes with suspected mendelian basis;
Alternative titles and symbols : Pseudotumor cerebri;
Description : Buchheit et al. (1969) described 2 sisters with idiopathic intracranial hypertension
with papilledema (pseudotumor cerebri). Traviesa et al. (1976) described 3 affected
sisters. The patients are typically young females who are obese and may be pregnant
or suffering from chronic dysfunctional uterine bleeding. Johnston and Morgan (1991)
described a mother and 2 of 4 daughters who had a diagnosis of pseudotumor cerebri
and 1 son who developed communicating hydrocephalus. Warner et al. (2002) quantified
vitamin A in the cerebrospinal fluid of patients with idiopathic intracranial hypertension,
elevated intracranial pressure of other causes, and normal intracranial pressure.
Vitamin A could be detected by high-pressure liquid chromatography in most of the
specimens. There was a significantly higher level of vitamin A in the cerebrospinal
fluid of some patients with idiopathic intracranial hypertension. The authors concluded
that vitamin A toxicity might play a role in the pathogenesis of idiopathic intracranial
hypertension. Katz et al. (2002) demonstrated the presence of both somatostatin receptor
types 1 (182451) and 2 (182452) in all samples of normal human choroid plexus and
arachnoid granulations. The authors proposed that these receptors might be involved
in the processes of cerebrospinal fluid production and absorption and, thus, might
play a role in the increased intracranial pressure of idiopathic intracranial hypertension.
*FIELD* SA Howe et al. (1973); Rothner and Burst (1974) *FIELD* RF 1. Buchheit, W.
A.; Burton, C.; Haag, B.; Shaw, D.: Familial papilledema and idiopathic intracranial
hypertension. New Eng. J. Med. 280: 938-942, 1969. 2. Howe, J.; Saunders, M.; Clarke,
P.: Familial benign intracranial hypertension. Acta Neurochir. 29: 173-175, 1973.
3. Johnston, I.; Morgan, M. K.: A familial coincidence of pseudotumor cerebri and
communicating hydrocephalus. Neurosurgery 28: 727-729, 1991. 4. Katz, S. E.; Klisovic,
D. D.; O'Dorisio, M. S.; Lynch, R.; Lubow, M.: Expression of somatostatin receptors
1 and 2 in human choroid plexus and arachnoid granulations: implications for idiopathic
intracranial hypertension. Arch. Ophthal. 120: 1540-1543, 2002. 5. Rothner, A.; Burst,
J.: Pseudotumor cerebri: report of a familial occurrence. Arch. Neurol. 30: 110-111,
1974. 6. Traviesa, D. C.; Schwartzman, R. J.; Glaser, J. S.; Savino, P. : Familial
benign intracranial hypertension. J. Neurol. Neurosurg. Psychiat. 39: 420-423, 1976.
7. Warner, J. E. A.; Bernstein, P. S.; Yemelyanov, A.; Alder, S. C.; Farnsworth, S.
T.; Digre, K. B.: Vitamin A in the cerebrospinal fluid of patients with and without
idiopathic intracranial hypertension. Ann. Neurol. 52: 647-650, 2002. *FIELD* CS;
Inheritance : Autosomal recessive;
Prefixed ID : 243200;
Origin ID : 243200;
UMLS CUI : C0033845;
Currated CISMeF NLP mapping
DO Cross reference
HPO term(s)
ORDO concept(s)
See also inter- (CISMeF)
Semantic type(s)
UMLS correspondences (same concept)