Preferred Label : Monosodium glutamate sensitivity;
Type : Other, mainly phenotypes with suspected mendelian basis;
Alternative titles and symbols : Chinese restaurant syndrome;
Description : Reif-Lehrer (1976) reported that 25% of persons develop the 'Chinese restaurant syndrome'
on exposure to monosodium glutamate (MSG) used as a flavor enhancer. Its heavy use
in soy sauce is the reason for association of its effects with Chinese restaurants.
He suggested that sensitive individuals may have an inborn error of metabolism. Symptoms
of the Chinese restaurant syndrome include tightness in the back of the neck, pressure
behind the eyes, frontal or temporal headache, facial flushing, nausea, etc. Family
and twin studies are needed. 'Hot dog' headache (Henderson and Raskin, 1972) and diet-induced
migraine (Youdim et al., 1971; Sandler et al., 1974) may be similar examples. *FIELD*
SA Alston (1976); Kuhar (1971) *FIELD* RF 1. Alston, R. M.: Chinese-restaurant syndrome.
(Letter) New Eng. J. Med. 294: 225 only, 1976. 2. Henderson, W. R.; Raskin, N. H.:
'Hot dog' headache: individual susceptibility to nitrite. Lancet 300: 1162-1163, 1972.
Note: Originally Volume II. 3. Kuhar, M. J.: A possible mechanism for pathogenic action
of monosodium glutamate. Res. Commun. Chem. Path. Pharm. 2: 95-97, 1971. 4. Reif-Lehrer,
L.: Possible significance of adverse reactions to glutamate in humans. Fed. Proc.
35: 2205-2212, 1976. 5. Sandler, M.; Youdim, M. E.; Hanington, E.: A phenylethylamine
oxidising defect in migraine. Nature 250: 335-337, 1974. 6. Youdim, M. B. H.; Carter,
S. B.; Sandler, M.: Conjugation defect in tyramine-sensitive migraine. Nature 230:
127-128, 1971. *FIELD* CS;
Inheritance : Autosomal recessive;
Prefixed ID : 231630;
Origin ID : 231630;
UMLS CUI : C0008127;
Currated CISMeF NLP mapping
- HPO term(s)
- Semantic type(s)
- UMLS correspondences (same concept)
