Type : Other, mainly phenotypes with suspected mendelian basis;
Description : Chang (1976) described a family in which a mother and all 4 of her daughters suffered
from vulvovaginal reactions to seminal fluid. Stinging, burning and pain in the vagina
developed during coitus or immediately after ejaculation and persisted for 2 to 72
hours. The vagina and vulva became red and swollen, with urticaria on the labia. Skin
tests showed a positive reaction to seminal fluid in 2 of 3 women tested. No sperm-agglutinating
antibody was detected, suggesting that the reaction is to components of semen other
than sperm. Benadryl (diphenhydramine) was effective therapy. *FIELD* RF 1. Chang,
T.-W.: Familial allergic seminal vulvovaginitis. Am. J. Obstet. Gynec. 126: 442-444,
1976. *FIELD* CS Autosomal dominant;
Currated CISMeF NLP mapping