Preferred Label : Urate oxidase, pseudogene;
Symbol : UOX;
CISMeF acronym : UOX; URICASE;
Type : Other, mainly phenotypes with suspected mendelian basis;
Alternative titles and symbols : URICASE;
Description : In most mammals, the activity of urate oxidase (EC 1.7.3.3) catalyzes the oxidation
of uric acid to allantoin; humans and some primates lack this enzyme activity. The
loss of urate oxidase in the human during primate evolution predisposes man to hyperuricemia,
a metabolic disturbance that can lead to gouty arthritis and renal stones (summary
by Wu et al., 1994).;
Prefixed ID : 191540;
Origin ID : 191540;
UMLS CUI : C3887994;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
