Preferred Label : Thiourea tasting;
Symbol : THIOT;
CISMeF acronym : THIOT;
Type : Phenotype, molecular basis known;
Included titles and symbols : Phenylthiocarbamide tasting; Ptc tasting; Propylthiouracil tasting; Prop tasting;
Description : The sense of bitter taste is mediated by a group of bitter taste receptor proteins
that reside on the surface of taste cells within the taste buds of the tongue. These
proteins are 7-transmembrane domain, G protein-coupled receptors that are encoded
by the TAS2R gene family (see TAS2R10; 604791), which contains at least 25 functional
genes (Kim et al., 2005). Humans worldwide display a bimodality in sensitivity to
the bitter taste of PTC, with approximately 75% of individuals perceiving it as intensely
bitter, whereas the rest perceive it as tasteless. This difference has been the basis
of study of taste perception in humans for over 70 years. Kim and Drayna (2004) provided
an historical review of the subject. Propylthiouracil (PROP) and PTC are members of
a class of compounds known as thioureas. The compounds carry the chemical group N-C
S, which is responsible for their characteristic bitter taste (Bartoshuk et al., 1994;
Drewnowski and Rock, 1995).;
Inheritance : Autosomal dominant; possibly two loci involved;
Prefixed ID : #171200;
Origin ID : 171200;
UMLS CUI : C1868397;
CISMeF manual mappings
- Genes related to phenotype
- Semantic type(s)
