Panic disorder 1

Preferred Label : Panic disorder 1;

Symbol : PAND1;

CISMeF acronym : PAND1;

Type : Phenotype or locus, molecular basis unknown;

Alternative titles and symbols : Panic disorder susceptibility locus, chromosome 13q-related;

Description : One locus for susceptibility to panic disorder (PAND1) has been mapped to chromosome 13q. The DSM-IV (American Psychiatric Association, 1994) defines panic disorder as the spontaneous, unexpected occurrence of panic attacks followed by persistent concern, worry, and anxiety about having additional panic attacks. Panic attacks are defined as a discrete period of intense fear or discomfort in which at least 4 of 13 symptom criteria are met that develop abruptly and reach a peak within 10 minutes. Some of these criteria include cardiac palpitations, sweating, feelings of choking, fear of losing control, and fear of dying. Panic disorder is divided into panic disorder with or without accompanying agoraphobia. However, agoraphobia can also occur without panic disorder, and panic attacks can occur in the absence of panic disorder. Comorbidity with depressive and addictive disorders is frequent. Barlow et al. (1994) and Smoller and Tsuang (1998) noted that because the diagnostic criteria remain purely clinical, the nosology of anxiety disorders, such as panic disorder, is controversial and evolving. Therefore, it is difficult to do genetic studies because of the difficulty in delineating overlapping phenotypes within the broader context of anxiety disorders. For example, there may be overlap of panic with specific phobias, variable expressivity of panic and anxiety or depression, or phenocopies within a family. The terms 'anxiety neurosis' and 'phobic neurosis' were used in the past (before the DSM-III in 1980) to encompass all of these disorders. Smoller and Tsuang (1998) suggested that dimensional personality traits, such as shyness, behavioral inhibition, and neuroticism (see 607834), could be used to define an anxiety phenotype. Schumacher et al. (2011) provided a review of the genetics of panic disorder. They noted that there is high (80%) comorbidity with other psychiatric disorders, including agoraphobia, mood disorders, substance abuse, and other anxiety disorders. Associated personality traits include anxiety sensitivity, behavioral inhibition, neuroticism, and harm avoidance. Women are more susceptible to development of the disorder, which has an average age of onset at 23.6 years. - Genetic Heterogeneity of Susceptibility to Panic Disorder See also PAND2 (607853), which has been mapped to chromosome 9, and;

Inheritance : ? Autosomal dominant form;

Prefixed ID : %167870;

Details

Origin ID

167870;

UMLS CUI

C1868649;

Automatic exact mappings (from CISMeF team)
- panic disorder with bladder conditions [MeSH Supplementary Concept]
- panic disorder with bladder conditions [MeSH concept]
- panic disorder with joint laxity [MeSH Supplementary Concept]
- panic disorder with joint laxity [MeSH concept]
Currated CISMeF NLP mapping
- Panic Disorder [NCIt concept]
- Panic disorder [MedDRA Preferred Term]
- Panic disorder (disorder) [SNOMED CT concept]
- Panic disorder NOS [MedDRA LLT]
- Panic disorder [episodic paroxysmal anxiety] [ICD-10 Sub-category]
- Panic disorder [episodic paroxysmal anxiety] [ICD-10 Sub-category (who)]
- panic disorder [Disease (Nov.)]
- panic disorder [MedlinePlus Topic]
- panic disorder [MeSH Descriptor]
- panic disorder [MeSH concept]
- panic disorder [DO Concept]
DO Cross reference
- panic disorder [DO Concept]
HPO term(s)
- Anxiety [HPO term]
- Autosomal dominant inheritance [HPO term]
Semantic type(s)
- Mental or Behavioral Dysfunction [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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